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Safrole: its metabolism, carcinogenicity and interactions with cytochrome p-450

Tipo de material: TextoTextoSeries ; Food Cosmet, Toxicol., p.657-666, 1981Trabajos contenidos:
  • Ioannides, C
  • Delaforge, M
  • Park, D. V
Recursos en línea: Resumen: A review of studies on safrole metabolism shows that the compound gives rise to a large number of metabolites by two major pathways, oxidation of the ally1 side chain and oxidation of the methylenedioxy group with subsequent cleavage to form a catechol. The mechanism by which safrole exerts the weak hepatocarcinogenicity that has been demonstrated in rats and mice is considered on the basis of published work and recent studies by the authors. Metabolic conversion of the ally1 group gives rise to intermediates capable of covalent binding with DNA and protein, and recent findings are compatible with conversion of the methylenedioxy group to a carbene, which forms ligand complexes with the haem moiety of cytochromes P-450 and P-448. It is suggested that while the ally1 group is responsible for the mutagenic potentia
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A review of studies on safrole metabolism shows that the compound gives rise to a large number of metabolites by two major pathways, oxidation of the ally1 side chain and oxidation of the methylenedioxy group with subsequent cleavage to form a catechol. The mechanism by which safrole exerts the weak hepatocarcinogenicity that has been demonstrated in rats and mice is considered on the basis of published work and recent studies by the authors. Metabolic conversion of the ally1 group gives rise to intermediates capable of covalent binding with DNA and protein, and recent findings are compatible with conversion of the methylenedioxy group to a carbene, which forms ligand complexes with the haem moiety of cytochromes P-450 and P-448. It is suggested that while the ally1 group is responsible for the mutagenic potentia

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