Functional tissue-engineered bone-like graft made of a fibrin scaffold and TG2 gene-modified EMSCs for bone defect repair (Record no. 53267)

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fixed length control field 02079nam a2200241Ia 4500
003 - CONTROL NUMBER IDENTIFIER
control field MX-MdCICY
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250625162425.0
040 ## - CATALOGING SOURCE
Transcribing agency CICY
090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN)
Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) B-19128
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245 10 - TITLE STATEMENT
Title Functional tissue-engineered bone-like graft made of a fibrin scaffold and TG2 gene-modified EMSCs for bone defect repair
490 0# - SERIES STATEMENT
Volume/sequential designation NPG Asia Materials, 13(1), p.1-18, 2021
520 3# - SUMMARY, ETC.
Summary, etc. The transplantation of tissue-engineered scaffolds with stem cells is a promising therapeutic approach for bone defect repair. To improve the therapeutic efficacy of this approach, in this study, a novel biofunctional live tissue-engineered bone-like graft was designed and constructed using a fibrin scaffold loaded with TG2 gene-modified ectomesenchymal stem cells (TG2-EMSCs)derived from nasal respiratory mucosa for bone defect repair. Autocalcification of the cell-free fibrin gel in osteogenic medium with additional alkaline phosphatase (ALP)and the osteogenic differentiation of TG2-EMSCs on the fibrin scaffold were assessed in vitro. The results indicated that the cell-free fibrin gel could autocalcify in the osteogenic medium with ALP and that the overexpression of TG2 by TG2-EMSCs could promote the osteogenic differentiation of these stem cells in the fibrin scaffold. Moreover, TG2 could enhance the deposition of extracellular matrix proteins in the fibrin scaffold, followed by calcification of the bone matrix in vitro. After transplantation into critical-sized cranial defects in rats, the functional tissue-engineered bone-like grafts improved bone regeneration. These results indicate that this tissue-engineered bone-like graft could improve the process of bone defect repair.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Shi, W.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Que, Y.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Zhang, X.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Bian, L.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Yu, X.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Tang, X.
700 12 - ADDED ENTRY--PERSONAL NAME
Personal name Lu, N.
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://drive.google.com/file/d/10wlsymg1Iyxu_s1sShPcdT3-zd1nWco8/view?usp=drivesdk">https://drive.google.com/file/d/10wlsymg1Iyxu_s1sShPcdT3-zd1nWco8/view?usp=drivesdk</a>
Public note Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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Source of classification or shelving scheme Clasificación local
Koha item type Documentos solicitados
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Lost status Source of classification or shelving scheme Damaged status Not for loan Collection Home library Current library Shelving location Date acquired Total checkouts Full call number Date last seen Price effective from Koha item type
  Clasificación local     Ref1 CICY CICY Documento préstamo interbibliotecario 25.06.2025   B-19128 25.06.2025 25.06.2025 Documentos solicitados