Comparative genome hybridization reveals widespread aneuploidy in Candida albicans laboratory strains

Tipo de material: Texto

TextoSeries ; Molecular MicroBiology, 55(5), p.1553-1565, 2005Trabajos contenidos:

Selmecki, A
Bergmann, S
Berman, J

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Resumen: Clinical strains of Candida albicans are highly tolerant of aneuploidies and other genome rearrangements. We have used comparative genome hybridization (CGH), in an array format, to analyse the copy number of over 6000 open reading frames (ORFs)in the genomic DNA of C. albicans laboratory strains carrying one (CAI-4)to three (BWP17)auxotrophies. We find that during disruption of the HIS1 locus all genes telomeric to HIS1 were deleted and telomeric repeats were added to a 9 nt sequence within the transforming DNA. This deletion occurred in ~ 10

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Clinical strains of Candida albicans are highly tolerant of aneuploidies and other genome rearrangements. We have used comparative genome hybridization (CGH), in an array format, to analyse the copy number of over 6000 open reading frames (ORFs)in the genomic DNA of C. albicans laboratory strains carrying one (CAI-4)to three (BWP17)auxotrophies. We find that during disruption of the HIS1 locus all genes telomeric to HIS1 were deleted and telomeric repeats were added to a 9 nt sequence within the transforming DNA. This deletion occurred in ~ 10

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