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In vitro anti-inflammatory activity of 3-O-methyl-flavones isolated from Siegesbeckia glabrescens

Tipo de material: TextoTextoSeries ; Bioorganic & Medicinal Chemistry Letters, 18(4), p.1511-1514, 2008Trabajos contenidos:
  • Kim, J.Y
  • Lim, H.J
  • Ryu, J.H
Recursos en línea: Resumen: Four flavones, 3,40-O-dimethylquercetin (1), 3,7-O-dimethylquercetin (2), 3-O-methylquercetin (3)and 3,7,40-O-trimethylquercetin (4)were isolated as the inhibitors of nitric oxide production in activated microglia (IC50 values: 11.1, 4.2, 3.8, and 25.1 lM, respectively). They suppressed the expression of protein and mRNA of inducible nitric oxide synthase. Furthermore, compounds 2 and 3 showed scavenging activity of peroxynitrite with SC50 values of 1.75 and 0.77 lM, respectively.
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Documentos solicitados Documentos solicitados CICY Documento préstamo interbibliotecario Ref1 B-9309 (Browse shelf(Opens below)) Available

Four flavones, 3,40-O-dimethylquercetin (1), 3,7-O-dimethylquercetin (2), 3-O-methylquercetin (3)and 3,7,40-O-trimethylquercetin (4)were isolated as the inhibitors of nitric oxide production in activated microglia (IC50 values: 11.1, 4.2, 3.8, and 25.1 lM, respectively). They suppressed the expression of protein and mRNA of inducible nitric oxide synthase. Furthermore, compounds 2 and 3 showed scavenging activity of peroxynitrite with SC50 values of 1.75 and 0.77 lM, respectively.

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