Interpretation of LOD Scores With a Set of Marker Loci

Tipo de material: Texto

TextoSeries ; Genetic Epidemiology, 1(4), p.357-362, 1984Trabajos contenidos:

Thompson, E.A

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Resumen: The problem discussed is that of interpreting LOD scores when multiple markers are tested for linkage with a particular disease locus. Provided the tests are based on independent segregations, both the maximum and the average LOD can be translated into a score that would have the same significance level were it the result of a single test.

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The problem discussed is that of interpreting LOD scores when multiple markers are tested for linkage with a particular disease locus. Provided the tests are based on independent segregations, both the maximum and the average LOD can be translated into a score that would have the same significance level were it the result of a single test.

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