HIV-1 Ribonuclease H Inhibitory Phenolic Glycosides from Eugenia hyemalis

Tipo de material: Texto

TextoSeries ; J. Nat. Prod., 71(9), p.1634-1636, 2008Trabajos contenidos:

Bokesch, H.R
Wamiru, A
Le Grice, S
Beutler, J.A
Mckee, T.C
Mcmahon, J.B

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Resumen: Three new galloyl arbutins, hyemalosides A-C (1-3), along with nine known compounds were isolated from the evergreen tree Eugenia hyemalis. The structures of compounds 1-3 were determined by analysis of NMR and MS data. Compounds 1-3 inhibited HIV-1 RNase H in Vitro with IC50 values of 1.46, >18, and 1.19 ìM, respectively. However, in a XTT-based cell viability assay using the human T-cell line CEM-SS infected with HIV-1RT, none of the compounds inhibited the cytopathic effect of HIV-1 infection at the highest dose tested (20 ìg/mL).

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Three new galloyl arbutins, hyemalosides A-C (1-3), along with nine known compounds were isolated from the evergreen tree Eugenia hyemalis. The structures of compounds 1-3 were determined by analysis of NMR and MS data. Compounds 1-3 inhibited HIV-1 RNase H in Vitro with IC50 values of 1.46, >18, and 1.19 ìM, respectively. However, in a XTT-based cell viability assay using the human T-cell line CEM-SS infected with HIV-1RT, none of the compounds inhibited the cytopathic effect of HIV-1 infection at the highest dose tested (20 ìg/mL).

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