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Influence of additives on melt viscosity, surface tension, and film formation of dry powder coatings

Tipo de material: TextoTextoSeries ; Drug Development and Industrial Pharmacy, 35(6), p.646-654, 2009Trabajos contenidos:
  • Sauer, D
  • Mcginity, J.W
Tema(s): Recursos en línea: Resumen: Background: Limited information on thermally cured dry-powder coatings used for solid dosage forms has been available in the literature. Aim: The aim of this study was to characterize the film formation process of Eudragit® L 100-55 dry-powder coatings and to investigate the influence of film additives on melt viscosity and surface tension. Methods: The coating process employed no liquids and the plasticizer was combined with the polymer using hot melt extrusion. Thermoanalytical methods including differential scanning calorimetry and thermogravimetric analysis (TGA)were used to investigate the thermal properties of the dry-coating formulations. The rheological behavior of the coating formulations were characterized with the extrusion torque, and the surface energy parameters were determined from contact angle measurements. The influence of the level of triethyl citrate (TEC)as plasticizer and polyethylene glycol (PEG)3350 in the polymer film on film formation was investigated using a digital force tester. Results: TGA confirmed thermal stability of all coating excipients at the investigated curing conditions. Increasing TEC levels and the addition of PEG 3350 as a low melting excipient in the coating reduced the viscosity of the polymer. Plasticization of the polymer with TEC increased the surface free energy, whereas the admixture of 10
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Documentos solicitados Documentos solicitados CICY Documento préstamo interbibliotecario Ref1 B-12189 (Browse shelf(Opens below)) Available

Background: Limited information on thermally cured dry-powder coatings used for solid dosage forms has been available in the literature. Aim: The aim of this study was to characterize the film formation process of Eudragit® L 100-55 dry-powder coatings and to investigate the influence of film additives on melt viscosity and surface tension. Methods: The coating process employed no liquids and the plasticizer was combined with the polymer using hot melt extrusion. Thermoanalytical methods including differential scanning calorimetry and thermogravimetric analysis (TGA)were used to investigate the thermal properties of the dry-coating formulations. The rheological behavior of the coating formulations were characterized with the extrusion torque, and the surface energy parameters were determined from contact angle measurements. The influence of the level of triethyl citrate (TEC)as plasticizer and polyethylene glycol (PEG)3350 in the polymer film on film formation was investigated using a digital force tester. Results: TGA confirmed thermal stability of all coating excipients at the investigated curing conditions. Increasing TEC levels and the addition of PEG 3350 as a low melting excipient in the coating reduced the viscosity of the polymer. Plasticization of the polymer with TEC increased the surface free energy, whereas the admixture of 10

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