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The antiviral activity of compounds isolated from Kenyan Carissa edulis (Forssk.)Vahl

Tipo de material: TextoTextoSeries ; Journal of Medicinal Plants Research, 4(15), p.1517-1522, 2010Trabajos contenidos:
  • Tolo, F. M
  • Rukunga, G. W
  • Muli, F. W
  • Ochora, J. M
  • Irungu, B. N
  • Muthaura, C. N
  • Wanjiku, C. K
  • Wanjiku, C. K
  • Ngoc, Q
  • Hashimoto, K
  • Asakawa, Y
Tema(s): Recursos en línea: Resumen: Extracts of a Kenyan medicinal plant, Carissa edulis (Forssk.)Vahl, were subjected to bioactivity guided phytochemical analysis for identification of biological makers of activity. Pure compounds; lupeol, oleuropein, carissol and ß-amyrin were subsequently isolated. In vitroevaluations of the compounds against viral strains of Herpes simples virustypes 1 revealed a significant activity for lupeolat EC 50 of between 2.98 - 4.2 µg/ml for both sensitive and resistant strains with a high therapeutic index (TI > 38). A concentration of the compound at 10.0 µg/ml was virucidal, reducing viral yields in Vero E6 cells by 98.3
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Documentos solicitados Documentos solicitados CICY Documento préstamo interbibliotecario Ref1 B-14923 (Browse shelf(Opens below)) Available

Extracts of a Kenyan medicinal plant, Carissa edulis (Forssk.)Vahl, were subjected to bioactivity guided phytochemical analysis for identification of biological makers of activity. Pure compounds; lupeol, oleuropein, carissol and ß-amyrin were subsequently isolated. In vitroevaluations of the compounds against viral strains of Herpes simples virustypes 1 revealed a significant activity for lupeolat EC 50 of between 2.98 - 4.2 µg/ml for both sensitive and resistant strains with a high therapeutic index (TI > 38). A concentration of the compound at 10.0 µg/ml was virucidal, reducing viral yields in Vero E6 cells by 98.3

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