Secondary Metabolites from Chamaedora tepejilote (Palmae)are Active against Mycobacterium tuberculosis

Tipo de material: Texto

TextoSeries ; Phytotherapy Research, 19(4), p.320-322, 2005Trabajos contenidos:

Jiménez, A
Meckes, M
Alvarez, V
Torres, J
Parra, R

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Resumen: Due to the emergence of multi-drug resistant Mycobacterium tuberculosis strains, there is an urgent need to search for new antimycobacterial drugs. The present work describes the bioactivity-guided fractionation of Chamaedora tepejilote hexane extract which led to the isolation and the characterization of squalene, farnesol, methylic ester of hexadecanoic acid, â -sitosterol and ursolic acid. Activity against Mycobacterium tuberculosis H37Rv, determined by radiorespirometric Bactec assay, showed ursolic acid, squalene and farnesol to produce a M. tuberculosis growth inhibition of 99

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Documentos solicitados	CICY Documento préstamo interbibliotecario	Ref1	B-7459 (Browse shelf(Opens below))	Available

Due to the emergence of multi-drug resistant Mycobacterium tuberculosis strains, there is an urgent need to search for new antimycobacterial drugs. The present work describes the bioactivity-guided fractionation of Chamaedora tepejilote hexane extract which led to the isolation and the characterization of squalene, farnesol, methylic ester of hexadecanoic acid, â -sitosterol and ursolic acid. Activity against Mycobacterium tuberculosis H37Rv, determined by radiorespirometric Bactec assay, showed ursolic acid, squalene and farnesol to produce a M. tuberculosis growth inhibition of 99

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