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DNA topoisomerase II? inhibitory and anti-HIV-1 flavones from leaves and twigs of Gardenia carinata.

Tipo de material: TextoTextoSeries ; Fitoterapia, 83(2), p.368-372, 2012Trabajos contenidos:
  • Kongkum, N
  • Tuchinda, P
  • Pohmakotr, M
  • Reutrakul, V
  • Piyachaturawat, P
  • Jariyawat, S
  • Napaswad, C
Tema(s): Recursos en línea: Resumen: Four new flavones, 5,2?-dihydroxy-7,3?,4?,5?-tetramethoxyflavone (1), 5,2?,5?-trihydroxy-7,3?,4?-trimethoxyflavone (2), 5,7,2?,5?-tetrahydroxy-6,3?,4?-trimethoxyflavone (3)and 5,2?,5?-trihydroxy-6,7,3?,4?-tetramethoxyflavone (4), along with the known 5,3?-dihydroxy-6,7,4?,5?-tetramethoxyflavone (5), 5,7,3?,5?-tetrahydroxy-6,4?-dimethoxyflavone (6), syringaldehyde, vanillic acid and scopoletin were isolated from the leaves and twigs of Gardenia carinata (Rubiaceae). Their structures were determined by spectroscopic methods. Flavone 2 exhibited cytotoxic activity against P-388 and MCF-7 cell lines, while 3, 5 and 6 were active only in P-388 cell line. All active compounds were found to inhibit DNA topoisomerase II? activity, which may be responsible for the observed cytotoxicity. Flavones 1-3, 5 and 6 also exhibited anti-HIV-1 activity in the anti-syncytium assay using ?Tat/revMC99 virus and 1A2 cell line system; 2 was most potent. Only flavones 1 and 6 showed considerably activity against HIV-1 reverse transcriptase.
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Documentos solicitados Documentos solicitados CICY Documento préstamo interbibliotecario Ref1 B-18301 (Browse shelf(Opens below)) Available

Four new flavones, 5,2?-dihydroxy-7,3?,4?,5?-tetramethoxyflavone (1), 5,2?,5?-trihydroxy-7,3?,4?-trimethoxyflavone (2), 5,7,2?,5?-tetrahydroxy-6,3?,4?-trimethoxyflavone (3)and 5,2?,5?-trihydroxy-6,7,3?,4?-tetramethoxyflavone (4), along with the known 5,3?-dihydroxy-6,7,4?,5?-tetramethoxyflavone (5), 5,7,3?,5?-tetrahydroxy-6,4?-dimethoxyflavone (6), syringaldehyde, vanillic acid and scopoletin were isolated from the leaves and twigs of Gardenia carinata (Rubiaceae). Their structures were determined by spectroscopic methods. Flavone 2 exhibited cytotoxic activity against P-388 and MCF-7 cell lines, while 3, 5 and 6 were active only in P-388 cell line. All active compounds were found to inhibit DNA topoisomerase II? activity, which may be responsible for the observed cytotoxicity. Flavones 1-3, 5 and 6 also exhibited anti-HIV-1 activity in the anti-syncytium assay using ?Tat/revMC99 virus and 1A2 cell line system; 2 was most potent. Only flavones 1 and 6 showed considerably activity against HIV-1 reverse transcriptase.

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