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The multitude of targets for the immune system and drug therapy in the fungal cell wall

Tipo de material: TextoTextoSeries ; Microbes and Infection, 7, p.789-798, 2005Trabajos contenidos:
  • Nimrichter, L
  • Rodrigues, M.L
  • Rodrigues, E.G
  • Travassos, L.R
Tema(s): Recursos en línea: Resumen: Recent studies on fungi revealed that several cytosolic and membrane components migrate to the cell wall together with secreted proteins and biosynthetic polysaccharides to build a dynamic immunoreactive structure. New aspects of fungal cell wall assembly and biosynthesis, focusing on the potential of glycolipids, melanin, heat-shock proteins, histone and surface antigens as targets of drugs and antifungal antibodies are discussed.
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Recent studies on fungi revealed that several cytosolic and membrane components migrate to the cell wall together with secreted proteins and biosynthetic polysaccharides to build a dynamic immunoreactive structure. New aspects of fungal cell wall assembly and biosynthesis, focusing on the potential of glycolipids, melanin, heat-shock proteins, histone and surface antigens as targets of drugs and antifungal antibodies are discussed.

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