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Omphalotin, A New Cyclic Peptide with Potent Nematicidal Activity from Omphalotus Olearius I. Fermentation and Biological Activity

Tipo de material: TextoTextoSeries ; Natural Product Letters, 10, p.25-32, 1997Trabajos contenidos:
  • Mayer, A
  • Anke, H
  • Sterner, O
Tema(s): Recursos en línea: Resumen: Omphalotin (l), a new cyclic peptide possessing strong and selective nematicidal activity against the plant pathogenic Meloidogyne incognita, was isolated from cultures of the basidiomycete Omphalotus olearius together with the antibiotic sesquiterpene illudin M (2)and the inactive 3-(3-indolyl)-Nmethylpropanamide (3). Omphalotin (1)is only weakly active against the saprophytic nematode Caenorhabditis elegans, it is weakly cytotoxic at 100 pg/ml but shows no phytotoxic, antibacterial or antifungal activities. The fermentation of 0. olearius and the production of the metabolites as well as the evaluation of their biological activities are reported.
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Omphalotin (l), a new cyclic peptide possessing strong and selective nematicidal activity against the plant pathogenic Meloidogyne incognita, was isolated from cultures of the basidiomycete Omphalotus olearius together with the antibiotic sesquiterpene illudin M (2)and the inactive 3-(3-indolyl)-Nmethylpropanamide (3). Omphalotin (1)is only weakly active against the saprophytic nematode Caenorhabditis elegans, it is weakly cytotoxic at 100 pg/ml but shows no phytotoxic, antibacterial or antifungal activities. The fermentation of 0. olearius and the production of the metabolites as well as the evaluation of their biological activities are reported.

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